General Information

• Project Title:

  Devices for advanced medical administration of drugs by transdermal route mediated by multifrequency focused ultrasound
• Project Title in the Original Language:

  Přístroje pro pokročilé medicínské podávání léčiv transdermání cestou zprostředkovanou multifrekvenčním fokusovaným ultrazvukem
• Project No.:

  FW06010087
• Provider:

  TA0 - Technology Agency of the Czech Republic (TA ČR)
• Programme:

  FW - TREND (2020 - 2027)
• Start of the Project:

  01. January 2023
• End of the Project:

  31. December 2027

The Goals of the Solution

• The Goals of the Solution:

  The aim of the project will be to develop devices designed for advanced medical administration of transdermal drugs by means of focused ultrasound. At present, the vast majority of drugs are administered orally or parenterally, most often by injection or infusion. These routes of administration are associated with drug degradation by the first-pass effect, problems with topical drug application, systemic patient burden, economic inefficiency and increasing environmental burden of drug residues. Targeted topical administration of the drug to the skin can solve this problem. The aim of the project is therefore to develop such devices that will allow the passage of the drug through the skin and its local application with a focus on the application of anti-inflammatory and vasodilatory drugs.
• Keywords:

  Percutaneous Penetration Enhancers Physical Methods; Sonophoresis; Cavitation Effect; High Intensity Focused Ultrasound; Penetration Pathways Through the Stratum Corneum; Therapeutic Application of Sonophoresis; Medical Devices for Sonophoresis

Beneficiary

• Beneficiary:

  FOTON s.r.o.
• Researcher:

  Dr. Ing. Jaroslav Moravec
• Other Researchers:

  Libor Kozák
  Ing. Tomáš Petráček
  Bc. Matěj Řehák
  Bc. Jiří Tuma

Other Project Participants

• Other Project Participant:

  Czech Technical University in Prague / Faculty of Biomedical Engineering
• Researcher:

  doc. PhDr. Ing. Jaroslav Průcha, CSc., Ph.D.
• Other Researchers:

  Karel Hána
  prof. MUDr. Leoš Navrátil, CSc., MBA, dr.h.c.
  Mgr. Josef Skopalík, Ph.D.

• Other Project Participantx:

  University of South Bohemia in České Budějovice / Faculty of Agriculture and Technology
• Researcher:

  doc. RNDr. Petr Bartoš, Ph.D.
• Other Researchers:

  Ing. Michaela Horčičková, Ph.D.
  doc. Ing. Roman Konečný, Ph.D.